Phd Thesis Nanoparticles

Phd Thesis Nanoparticles-58
This feat can be aided by the attachment of additional functionalmolecules such as cell penetrating peptides (CPPs), targeting peptides,additional drug types and molecules for imaging during treatment.

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Gold nanoparticles (Au NPs) have emerged as a promising platform for a myriad of biomedical applications, including sensing, drug delivery, and antibiotics.

The responsiveness of this system demonstrates the utility of co-engineering synthetic-biological hybrid nanomaterials.

Moreover, I developed gold nanoparticle-stabilized nanocapsules (NPSCs) for gene delivery to enhance cancer therapy and immunomodulation efficiency.

In summary, the findings in this thesis highlight that systematically tuning the physicochemical properties of nanoparticles provides a powerful means to control interactions with biological systems, enabling new biological and therapeutic applications.

The exploitation of various inorganic nanoparticles as drug carriers and therapeutics is becoming increasingly common.It is essentialfor new designs to be extensively tested for toxicity and efficiency in humancells before they can be successfully released into the clinic.As part of this effort, this Ph D project has investigated two different NP designstrategies for drug delivery: 1) the use of a magnetic field (MF) and a CPP toincrease the delivery of iron oxide magnetic NPs (m NPs) to cells grown in tissueequivalent3D collagen gels, and 2) gold NPs (Au NPs) for the delivery of si RNA tosilence the c-myc oncogene for cancer treatment.Modern day medicine is on the brink of a new age of therapy, which aims toharness the natural power of molecular biology for disease treatment.Thistherapy could include replacement of dysfunctional genes that cause disorderssuch as cystic fibrosis (Lommatzsch and Aris, 2009), or silencing the overexpressionof genes that cause disorders such as cancer (Pelengaris and Khan,2003).In the first investigation, a MFand the CPP penetratin were found to increase m NP delivery to cells grown in3D.In the second investigation, Au NPs were assessed in a range of different celltypes (grown in 2D) for their performance in 4 main areas; cellular toxicity,cellular uptake, c-myc knockdown and effect on the cell cycle.In this thesis, I have studied and engineered the interface of Au NPs with different biological systems, demonstrating a large variety of biomedical applications by modulation of these interfaces.My research was initially focused on systematically tuning the physicochemical properties of nanoparticles to understand nano-bio interactions at the cellular level. Functionalized SPIONs demonstrated the ability of specific labeling. Furthermore, the hydrophilic SPIONs were stable in vitro in serums and cells as well as in vivo in mice.


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