Protein Structure Prediction Essay

Protein Structure Prediction Essay-61
Very large aggregates can be formed from protein subunits.For example, many thousands of actin molecules assemble into a microfilament.Secondary structure refers to highly regular local sub-structures on the actual polypeptide backbone chain.

Very large aggregates can be formed from protein subunits.For example, many thousands of actin molecules assemble into a microfilament.Secondary structure refers to highly regular local sub-structures on the actual polypeptide backbone chain.

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Protein structures range in size from tens to several thousand amino acids.

By physical size, proteins are classified as nanoparticles, between 1–100 nm.

They should not be confused with random coil, an unfolded polypeptide chain lacking any fixed three-dimensional structure.

Several sequential secondary structures may form a "supersecondary unit".

Both the α-helix and the β-sheet represent a way of saturating all the hydrogen bond donors and acceptors in the peptide backbone.

Some parts of the protein are ordered but do not form any regular structures.The folding is driven by the non-specific hydrophobic interactions, the burial of hydrophobic residues from water, but the structure is stable only when the parts of a protein domain are locked into place by specific tertiary interactions, such as salt bridges, hydrogen bonds, and the tight packing of side chains and disulfide bonds.The disulfide bonds are extremely rare in cytosolic proteins, since the cytosol (intracellular fluid) is generally a reducing environment.For example, insulin is composed of 51 amino acids in 2 chains.One chain has 31 amino acids, and the other has 20 amino acids.The sequence of amino acids in insulin was discovered by Frederick Sanger, establishing that proteins have defining amino acid sequences.The sequence of a protein is unique to that protein, and defines the structure and function of the protein.A single amino acid monomer may also be called a residue indicating a repeating unit of a polymer.Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond.The primary structure of a protein refers to the sequence of amino acids in the polypeptide chain.The primary structure is held together by peptide bonds that are made during the process of protein biosynthesis.

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